OptiNOs Strength and Endurance Trial in Resistance-Trained Men
Resistance-trained men taking 750 mg of OptiNOs a day added an average of 27 kg (60 lb) to their bench press over 6 weeks, compared with 3 kg (6 lb) on placebo.
Summary
Forty resistance-trained men followed a supervised program four days a week for six weeks, taking either 750 mg of OptiNOs a day or a placebo. The OptiNOs group added about 60 lb to their bench press and 82 lb to their leg press, compared with about 6 lb and 7 lb on placebo, and did more reps to exhaustion.
Context Note
Sponsor-run and unpublished. Lean mass, body fat and lactate did not differ from placebo.
Study breakdown
Why this study was done
OptiNOs is a blend of Cissus quadrangularis, Curcuma longa and Trachyspermum ammi extracts. Laila Nutraceuticals tested whether it changes strength, endurance and muscle size in men who already train.
How it was run
- Randomized, double-blind, placebo-controlled, at one site in India, March to August 2014.
- 40 healthy resistance-trained men aged 18 to 40 were randomized, 20 per group. 36 completed.
- Each took two 375 mg capsules a day (750 mg) of OptiNOs or a matching placebo for 42 days.
- Everyone trained four days a week with a physical trainer present.
What they found
- Bench press one-rep max rose 27.3 kg (about 60 lb) on OptiNOs, compared with 2.8 kg (about 6 lb) on placebo (p less than 0.0001).
- Leg press one-rep max rose 37.3 kg (about 82 lb), compared with 3.2 kg (about 7 lb) on placebo (p less than 0.0001).
- Reps to exhaustion rose by 6.7, compared with 1.5 on placebo (p less than 0.0001).
- The OptiNOs group pulled ahead on all three by day 14.
- Upper-arm size rose about 0.5 cm, compared with less than 0.1 cm on placebo.
- One mild fever was reported and judged unrelated. No serious adverse events.
Limitations
One small trial, run and paid for by the ingredient maker, not published or peer reviewed. Analysis covered completers only. Lean mass, body fat and blood lactate did not differ from placebo. The OptiNOs group started with larger arms and a higher leg press. Diet was not reported.
What it means in practice
The results apply to trained men on a supervised program at 750 mg a day. They were not tested in women, teens or people who do not train.
Study Type
Sponsor Trial (Unpublished)
Published
2014
Unpublished sponsor trial
Participants
40 resistance-trained men aged 18 to 40, 36 completed, 6 weeks of supervised training
Dose Studied
750 mg per day of OptiNOs (LI89034F2), two 375 mg capsules
Health Focus
No items found.
Ingredients
OptiNOs
Frequently Asked Questions
Are these formulas safe to take with medication?
That depends on the specific medication and formula. A few, like blood thinners with CurQLife or blood pressure medication with MaxiNOs, are worth a direct conversation with your doctor first. Check each formula's own FAQ section for specifics, or ask your health coach.
Do all four formulas have the same level of research behind them?
No, and we'd rather be upfront about it. Bacopa, the plant in BacoZest, has published human studies, though they used other bacopa extracts. OptiNOs and MaxiNOs each have human studies sponsored by their maker, Laila Nutraceuticals, which haven't been published in a journal. CurQLife's research is still early, from lab and animal studies, and we label it that way.
Which formula is right for me?
It depends on what you're building your routine around. BacoZest is built around bacopa, which is studied for memory.* OptiNOs supports strength and muscular endurance alongside resistance training.* MaxiNOs was studied for healthy blood vessel function.* CurQLife's research is still at the lab stage. Your health coach can help you pick a starting point.
Are these ingredients safe?
All four are built around plant extracts. OptiNOs was reported as well tolerated in its human study, and published bacopa studies reported no serious side effects. CurQLife's safety data so far comes from lab and animal testing. Check with your doctor first if you're pregnant, nursing, on medication, or managing a health condition.
Why are patented ingredients more expensive?
Because the patented ingredients behind our four formulas went through dedicated research, and research costs real money. A generic curcumin or bacopa supplement hasn't been tested in the form you get from us. You're paying for an ingredient with research behind it, not just a label.
What makes The Collection different from other brands?
Generic ingredients often haven't been studied in the specific form you're buying. Our four core formulas use patented ingredients, and we show you the research behind each one, including where it's still early.
How long until I notice results?
It depends on the formula. In its study, MaxiNOs blood vessel response was higher than placebo 2 to 3 hours after the first dose.* OptiNOs and bacopa were studied over 6 and 12 weeks of daily use, so give them time. CurQLife is meant to be taken daily.
Can I take all four together?
Yes. BacoZest, OptiNOs, MaxiNOs, and CurQLife are built for different goals, and none of them contain stimulants. They haven't been studied together, so ask your health coach how to fit them into your routine.
