MaxiNOs Blood Vessel Function Trial (Flow-Mediated Dilation)
Flow-mediated dilation rose from 10.25% to 16.71% over 42 days with 375 mg of MaxiNOs a day, higher than placebo from the first dose on.
Summary
Physically active adults aged 30 to 65 took 375 mg or 750 mg of MaxiNOs a day, or a placebo, for 42 days. Flow-mediated dilation, which measures how well the arm artery widens, rose in both MaxiNOs groups and was higher than placebo 2 to 3 hours after the first dose and at days 21 and 42.
Context Note
Sponsor-run and unpublished; only a results summary is available, without placebo values or p-values.
Study breakdown
Why this study was done
Flow-mediated dilation (FMD) measures how much an artery widens when blood flow increases, a marker of healthy blood vessel function. Laila Nutraceuticals tested whether MaxiNOs changes it.
How it was run
- Randomized, double-blind, placebo-controlled, with 25 people in each group: placebo, 375 mg or 750 mg of MaxiNOs a day for 42 days.
- Participants were physically active adults aged 30 to 65 with a BMI of 25 to 29 and slightly elevated blood pressure.
- FMD was measured before the first dose, 2 to 3 hours after it, and at days 21 and 42.
What they found
- At 375 mg, FMD rose from 10.25% to 14.00% within 2 to 3 hours, 16.44% at day 21 and 16.71% at day 42, higher than placebo at each point.
- At 750 mg, FMD rose from 10.09% to 18.67% by day 42, higher than placebo at each point.
- Peak artery diameter rose in both groups, higher than placebo.
- Grip strength at 750 mg rose from 34.50 to 37.65 kg, higher than placebo at days 21 and 42.
Limitations
Only a summary table is available, without placebo values or p-values. The study was run by the ingredient maker and has not been published. At 375 mg, the nitric oxide change was not significant and grip strength beat placebo only at day 21. FMD is a lab measure of blood vessel response, not a measure of pumps or endurance, which were not measured.
What it means in practice
The results apply to active adults aged 30 to 65 taking MaxiNOs daily. They were not tested in younger athletes or teens.
Study Type
Sponsor Trial (Unpublished)
Published
2022
Unpublished sponsor trial (summary data)
Participants
About 75 physically active adults aged 30 to 65, BMI 25 to 29, 42 days
Dose Studied
375 mg or 750 mg per day of MaxiNOs (CL89032F3)
Health Focus
No items found.
Ingredients
MaxiNOs
Frequently Asked Questions
Are these formulas safe to take with medication?
That depends on the specific medication and formula. A few, like blood thinners with CurQLife or blood pressure medication with MaxiNOs, are worth a direct conversation with your doctor first. Check each formula's own FAQ section for specifics, or ask your health coach.
Do all four formulas have the same level of research behind them?
No, and we'd rather be upfront about it. Bacopa, the plant in BacoZest, has published human studies, though they used other bacopa extracts. OptiNOs and MaxiNOs each have human studies sponsored by their maker, Laila Nutraceuticals, which haven't been published in a journal. CurQLife's research is still early, from lab and animal studies, and we label it that way.
Which formula is right for me?
It depends on what you're building your routine around. BacoZest is built around bacopa, which is studied for memory.* OptiNOs supports strength and muscular endurance alongside resistance training.* MaxiNOs was studied for healthy blood vessel function.* CurQLife's research is still at the lab stage. Your health coach can help you pick a starting point.
Are these ingredients safe?
All four are built around plant extracts. OptiNOs was reported as well tolerated in its human study, and published bacopa studies reported no serious side effects. CurQLife's safety data so far comes from lab and animal testing. Check with your doctor first if you're pregnant, nursing, on medication, or managing a health condition.
Why are patented ingredients more expensive?
Because the patented ingredients behind our four formulas went through dedicated research, and research costs real money. A generic curcumin or bacopa supplement hasn't been tested in the form you get from us. You're paying for an ingredient with research behind it, not just a label.
What makes The Collection different from other brands?
Generic ingredients often haven't been studied in the specific form you're buying. Our four core formulas use patented ingredients, and we show you the research behind each one, including where it's still early.
How long until I notice results?
It depends on the formula. In its study, MaxiNOs blood vessel response was higher than placebo 2 to 3 hours after the first dose.* OptiNOs and bacopa were studied over 6 and 12 weeks of daily use, so give them time. CurQLife is meant to be taken daily.
Can I take all four together?
Yes. BacoZest, OptiNOs, MaxiNOs, and CurQLife are built for different goals, and none of them contain stimulants. They haven't been studied together, so ask your health coach how to fit them into your routine.
